低频rTMS与risperidone结合对慢性精神分裂症住院患者的肠道微生物群的影响
Rui Li1, Rui Fu1, Zhi-Quan Cui1
1Department of Psychiatry, Chang'an Hospital, Xi'an 710000, China.
Brain research
|August 20, 2023
概括
在精神分裂症患者中,重复性横磁刺激 (rTMS) 结合瑞斯佩里改变了肠道细菌. 特定细菌的变化,如蛋白质细菌和Lacknospiraceae,可能有助于治疗的有效性.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 精神病学是一个精神病学.
背景情况:
- 重复性横磁性刺激 (rTMS) 是对精神分裂症 (SCH) 的常见治疗方法.
- 低频rTMS与抗精神病药物结合对慢性SCH肠道微生物群的影响仍未得到充分研究.
- 人们越来越认识到大脑-肠-微生物群轴在精神健康障碍中的作用.
研究的目的:
- 调查rTMS与RISPERIDONE结合对慢性精神分裂症患者肠道微生物组合的影响.
- 探索肠道微生物群变化与这种联合治疗的治疗效果之间的潜在相关性.
主要方法:
- 在33名慢性SCH患者的便样本上进行了16S rRNA基因测序,在基线时,27名患者接受了2周治疗 (SCH-2W),37名健康对照 (HC).
- 在整个研究期间,评估了精神病症状.
主要成果:
- 与基线和HC相比,在接受rTMS和Risperidone治疗的SCH患者中观察到肠道微生物群的显著变化.
- 蛋白质菌,肠杆菌和埃舍里希亚-西格拉菌的减少,以及norank_f_Lachnospiraceae的增加也被注意到.
- 这些微生物转移可能与联合治疗的抗精神病疗效有关.
结论:
- 低频rTMS和risperidone的组合会影响慢性精神分裂症患者的肠道微生物组合.
- 在特定的细菌种群中观察到的变化表明大脑-肠-微生物群轴在RTMS和精神分裂症抗精神病治疗的治疗机制中参与.
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