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随着血管并发症的AGE积累,血糖控制和代谢综合征:叙述性综述
Rimesh Pal1, Sanjay K Bhadada1
1Department of Endocrinology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, India.
先进的糖化终产物 (AGEs) 从高血糖形成,并导致糖尿病并发症. 减少AGE可以预防或治疗诸如视网膜病变和动脉样硬化等疾病.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 分子生物学分子生物学
背景情况:
- 糖尿病涉及多种机制,导致微血管和宏血管并发症.
- 先进的糖化终产物 (AGEs) 与这些糖尿病并发症有很大关系.
研究的目的:
- 审查关于AGE形成的文献.
- 探索AGE在糖尿病中微和宏血管并发症中的作用.
主要方法:
- 关于AGE形成和糖尿病并发症的研究的文献综述.
- 分析将AGE与病变发生联系在一起的机制.
主要成果:
- 高血糖症通过非酶体糖化驱动AGE的形成.
- AGEs积累,导致交叉链接和激活RAGE,导致氧化应激.
- AGEs有助于糖尿病视网膜病变,病,神经病变,骨病,动脉样硬化和NAFLD.
- 高AGE水平与糖尿病并发症相关;饮食AGE促进代谢综合征.
结论:
- 先进的糖化终产物 (AGEs) 是糖尿病并发症病变发生的关键媒介.
- 针对AGE的形成或行动可能为糖尿病提供治疗策略.
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