COVID-19感染和肺纤维化之间的关联:一个嵌套的病例控制研究
Ronza Najjar-Debbiny1, Ofra Barnett-Griness2, Johad Khoury3
1Infection Control and Prevention Unit, Lady Davis Carmel Medical Center, Haifa, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
The American journal of medicine
|August 20, 2023
概括
冠状病毒疾病 (COVID-19) 显著增加肺纤维化风险,特别是严重疾病. 这一关联凸显了COVID-19感染后的一个关键的长期健康问题.
科学领域:
- 肺部医学 肺部医学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 肺纤维化是一种严重的疾病,对其与COVID-19的联系的理解有限.
- 目前关于COVID-19和肺纤维化之间的联系的数据很少.
研究的目的:
- 调查COVID-19与随后肺纤维化发展之间的关联.
- 为了确定COVID-19的严重程度是否影响肺纤维化风险.
主要方法:
- 一项嵌套病例对照研究在以色列一大群超过28万成年人中进行.
- 1284名被诊断为肺纤维化患者与12840名对照人群进行了匹配.
- 实施了60天的延迟时间,以减轻评估COVID-19病史和严重程度的监测偏见.
主要成果:
- 与没有COVID-19的患者相比,患有COVID-19的患者患肺纤维化病的几率增加了1.80倍.
- 随着COVID-19的严重程度,肺纤维化风险增加:轻度,中度和重度病例的几率比分分别为1.33,2.98和9.30.
- 即使有180天的延迟,严重的COVID-19仍然与肺纤维化风险更高相关.
结论:
- COVID-19 与肺纤维化风险增加有关.
- 在COVID-19之后肺纤维化风险与最初感染的严重程度直接相关.
相关概念视频
01:20COPD: Pathogenesis and Clinical Features
341
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
341
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.8K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.8K
01:30Pulmonary Hypertension: Classification and Pathogenesis
222
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
There are various classifications for PH, each relating to different underlying causes and also...
222
01:29Pneumonia II: Pathophysiology
336
The pathophysiology of pneumonia involves the following steps:
336
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
2.8K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
2.8K
01:30Pneumonia I: Introduction
268
Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
268