胆道癌的辅助和新辅助化疗:随机对照试验的综述
Kohei Nakachi1, Naoto Gotohda2, Etsuro Hatano3
1Department of Medical Oncology, Tochigi Cancer Center, Utsunomiya, Japan.
Japanese journal of clinical oncology
|August 20, 2023
概括
自2002年以来,胆道癌的辅助化疗已经发展起来,如今,口服胺类药物 (如capecitabine和S-1) 已成为标准治疗方法. 本综述审查了随机对照试验的有效性.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 临床试验 临床试验
背景情况:
- 对于胆道癌 (BTC) 辅助化疗的第一个随机对照试验 (RCT) 于2002年发表.
- 随后的研究已经证明了口服皮里米丁的疗效,包括capecitabine (2018) 和S-1 (2023).
- 口服胺现在被认为是BTC中辅助化疗的标准护理.
研究的目的:
- 审查完成的随机对照试验 (RCT) 的证据,评估胆道癌症的辅助化疗.
- 总结正在进行的RCT和未报告结果的试验的发现.
- 为BTC提供目前辅助化疗的现状概述.
主要方法:
- 发表的随机对照试验的系统审查.
- 包括正在进行的和未发表的研究数据.
- 在BTC的辅助剂环境中分析口服胺的疗效数据.
主要成果:
- 卡佩西塔在2018年证明了它的有效性.
- 在2023年,S-1显示出有效性.
- 口服胺已被确立为BTC的标准辅助化疗.
结论:
- 随机对照试验已经确立了口服胺作为胆道癌症的有效辅助化疗.
- 随着正在进行的和最近报告的研究,证据基础继续增长.
- 使用口服皮里米丁的辅助化疗代表了BTC治疗的重大进展.
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