对无症状静脉血栓栓塞的里瓦罗克萨班治疗:J'exactly研究的见解
Shohei Migita1, Yasuo Okumura2, Ikuo Fukuda3
1Division of Cardiology, Department of Medicine, Nihon University School of Medicine, Ohyaguchi-kamicho, Itabashi-ku, Tokyo, 173-8610, Japan.
Thrombosis journal
|August 20, 2023
概括
对肺栓塞或深静脉血栓形成的有症状和无症状患者,利瓦洛克萨班治疗的安全性和有效性相似. 这表明,利瓦洛克萨班是治疗无症状静脉血栓栓塞的可行选择.
科学领域:
- 心脏病学 心脏病学
- 血管医学 血管医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 在日本,无症状肺栓塞 (PE) 和深静脉血栓塞 (DVT) 的治疗策略尚未成熟.
- 这项研究通过比较症状与无症状静脉血栓栓塞 (VTE) 患者的特征和结果来解决这种不确定性.
- 了解这些差异对于优化VTE管理至关重要.
研究的目的:
- 为了澄清无症状与有症状的PE和DVT患者的临床特征.
- 为了比较症状和无症状VTE患者之间的结果,包括复发性VTE和严重出血.
- 评估里瓦罗克萨班在治疗无症状VTE时的安全性和有效性.
主要方法:
- 在日本进行的J'exactly研究的前性,多中心子分析.
- 包括1,016名被诊断患有静脉血栓塞栓症 (VTE) 的患者.
- 治疗里瓦罗克萨班,剂量和持续时间由医生调整.
主要成果:
- 与症状PE患者相比,无症状PE患者 (47%的PE队列) 患有更高的活跃癌症率和更低的近道DVT严重程度.
- 无症状的DVT患者 (34%的DVT队列) 年龄较大,女性更频繁,活跃癌症和远端DVT的发病率更高.
- 在无症状和有症状的PE或DVT患者之间,在复发性症状性VTE或严重出血的发生率上没有发现显著差异.
结论:
- 现实世界的数据表明,在无症状和症状PE/DVT患者中,里瓦洛克萨班治疗的复合不良事件发生率相似.
- 医生调整的里瓦罗克萨班剂量和持续时间显示出有利的安全性.
- 这些发现支持利瓦洛克萨班在治疗无症状VTE的潜在用途.
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