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随着时间的推移,淋巴细胞和质结肠炎的发病率存在区域差异
Johanna Kristina Larsson1,2, Spencer Clarkson3, Klas Sjoberg1,2
1Department of Clinical Sciences, Lund University, Malmö, Sweden.
Scandinavian journal of gastroenterology
|August 21, 2023
概括
淋巴细胞性结肠炎 (LC) 的发病率从2015年至2020年在瑞典斯卡内显著增加,与稳定的原性结肠炎 (CC) 率不同. 这表明LC可能有不同的环境原因,需要进一步调查.
科学领域:
- 胃肠病学 胃肠病学
- 流行病学 流行病学
- 病理学 病理学 病理学
背景情况:
- 显微性结肠炎 (MC) 的发生率在全球范围内有所上升.
- 这项研究重点关注瑞典斯卡内MC亚型的时间和空间变化.
- 调查发病率趋势对于了解MC流行病学至关重要.
研究的目的:
- 为了确定淋巴细胞结肠炎 (LC) 和质结肠炎 (CC) 在瑞典斯卡内 (2010-2020) 的发病率.
- 分析这些MC亚型发生率的时间和空间变化.
- 根据发病率模式,探索LC和CC之间的潜在差异.
主要方法:
- 从病理学活检记录中检索了MC诊断.
- 适用于LC (淋巴细胞增加) 和CC (原带) 的确定的诊断标准.
- 收集的患者数据包括年龄,性别,诊断日期和居住城市.
主要成果:
- 确定了1985名MC患者 (平均年龄62.9岁,71%为女性).
- 质结肠炎 (CC) 的发病率保持稳定 (ASR为6.34/100,000人年).
- 淋巴细胞结肠炎 (LC) 发病率在2015-2020年间显著增加 (ASR在2019年达到15.2),西北斯科内地区的发病率更高.
结论:
- 稳定的CC发病率与LC的显著增加形成鲜明对比,表明不同的疾病实体.
- 癌症发病率的快速增长可能表明环境因素,需要进一步研究.
- 特定的LC的时间和空间模式强调了需要持续的流行病学监测.
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