在2019年冠状病毒病 (Covid-19) 危急病患者中可能忽略过渡性 (T) 多聚质化
- Gasim Dobie1, - Hassan A Hamali1, - Abdullah A Mobarki1
1Department of Medical Laboratory Technology, Jazan University, Gizan, Saudi Arabia.
Pakistan journal of pharmaceutical sciences
|August 21, 2023
概括
严重的COVID-19患者可能会出现T细胞激活和红细胞多聚化. 这项研究发现,34.3%的重症监护病房患者表现出这些变化,可能与病毒有关.
科学领域:
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
- 病毒学 病毒学
背景情况:
- T-激活多聚聚化与细菌/病毒感染和溶血性贫血有关.
- 冠状病毒疾病-19 (COVID-19) 也与血液溶解性贫血有关.
研究的目的:
- 在重症COVID-19患者中调查T激活多聚质化的存在和患病率.
主要方法:
- 用来自COVID-19患者的红细胞化抗T Arachis hypogaea lectin. 这是一个非常好的方法.
- 对凝结的观察表明T-激活和多聚凝结.
主要成果:
- 在重症监护室 (ICU) 的COVID-19患者中,有34.3%的患者表现出T激活多聚合的迹象.
- 在这些患者中观察到导致凝结的密码抗原暴露.
结论:
- 在接受ICU治疗的COVID-19患者中发现抗T的高患病率.
- 严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 可能在体外诱导短暂的T-激活和多聚合.
- 这些发现表明,在重症COVID-19患者体内血液溶解的潜在机制.
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