帕金森病中的焦虑与大脑结构连接的变化有关
Guillaume Carey1,2,3, Romain Viard4, Renaud Lopes1,4
1Univ. Lille, Inserm, CHU Lille, U1172 - LilNCog - Lille Neuroscience & Cognition, Lille, France.
Journal of Parkinson's disease
|August 21, 2023
概括
帕金森病的焦虑与大脑电路中的微观结构变化有关. 扩散张力成像 (DTI) 在患有焦虑症的PD患者中显示出明显的WM变化.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 帕金森病 (PD) 中的焦虑与灰质和功能性大脑变化有关.
- 之前的研究没有研究PD患者焦虑的白质 (WM) 变化.
研究的目的:
- 为了识别PD患者和无焦虑的PD患者的特定WM变化.
- 使用扩散张力成像 (DTI) 来比较这些组之间的WM完整性.
主要方法:
- 分析了108名非痴呆PD患者 (31名患有焦虑症,77名没有).
- 扩散张力成像 (DTI) 测量了与焦虑相关的区域的分数异构性 (FA) 和平均扩散性 (MD).
- WM指标与焦虑严重程度相关,根据临床因素进行调整.
主要成果:
- 患有焦虑症的PD患者在多个WM通道中表现出改变的FA和MD,包括条纹-轨道-前额,条纹-状和尾状-胸膜通道.
- 具体发现包括某些路段的较低FA和其他路段的较高FA,以及不同的MD值.
- 这些微观结构变化在与焦虑相关的关键神经元电路中被观察到.
结论:
- 帕金森病中的焦虑与WM中可证明的微观结构变化有关.
- 这些发现支持了与PD相关的焦虑与相关大脑电路内的结构变化之间的联系.
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