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相关概念视频

Translation01:31

Translation

15.0K
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Proteins are...
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Lysosomal Hydrolases01:22

Lysosomal Hydrolases

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Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
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Amyloid Fibrils03:03

Amyloid Fibrils

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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Caenorhabditis elegans as a Model System for Discovering Bioactive Compounds Against Polyglutamine-Mediated Neurotoxicity
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PolyQ数据库 - 一个综合的数据库关于多重质胺的疾病.

Bernardo Estevam1,2, Carlos A Matos1,2, Clévio Nóbrega1,2

  • 1ABC-Ri, Algarve Biomedical Center Research Institute, Campus de Gambelas, Faro 8005-139, Portugal.

Database : the journal of biological databases and curation
|August 21, 2023
PubMed
概括

多重氨酸 (polyQ) 疾病是罕见的神经退行性疾病. 一个新的免费在线数据库集中了所有九种多Q疾病的信息,帮助研究人员和患者.

科学领域:

  • 神经遗传学 神经遗传学
  • 分子生物学分子生物学
  • 罕见疾病 罕见疾病

背景情况:

  • 多重氨酸 (polyQ) 疾病是九种罕见的单一性神经退行性疾病的一组.
  • 这些条件是由于特定基因中的扩展的氨酸,氨酸,氨酸 (CAG) 三重重复导致的,导致蛋白质结构异常.
  • 目前,没有治愈方法,信息在各种来源中分散.

研究的目的:

  • 创建一个集中,免费的在线资源,提供所有九种多Q疾病的全面信息.
  • 通过整合分散的数据来支持研究人员,临床医生,患者和家庭.

主要方法:

  • 开发一个专门的在线平台,PolyQ数据库.
  • 汇集涵盖流行病学,致病基因,蛋白质特征,病理生理学和临床表现的信息.
  • 确保数据库不断更新和可扩展.

主要成果:

  • 启动了PolyQ数据库 (https://polyq.pt/),作为第一个专注于所有9种polyQ疾病的平台.
  • 它提供了一个统一的信息来源,与不同的受众相关.
  • 该平台旨在持续更新和传播信息.

结论:

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  • PolyQ数据库解决了对这些罕见的神经退行性疾病的集中信息的关键需求.
  • 本资源为科学和公共利益提供了对多Q疾病的更好的理解和探索.
  • 该数据库旨在成为不断发展的PolyQ疾病知识中心.