普鲁西酸盐是一种来自Pax Dioscorea preussii的新型尿素酶抑制酸盐
Muhammad Shaiq Ali1, Seerat Iqbal1, Mehreen Lateef2
1H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.
Natural product research
|August 21, 2023
概括
对Dioscorea preussii的植物化学分析产生了一种新型的酸盐,酸盐和10种已知的化合物. 几种分离物体表现出显著的抗氧化和尿酶抑制活性,而前述物体显示出强烈的尿酶抑制.
科学领域:
- 植物化学 植物化学
- 自然产品 化学 化学
- 药理学 药理学是指药理学的学科.
背景情况:
- Dioscorea preussii是一种具有潜在药用应用的植物物种.
- 人种植物学用途表明,这种植物中存在生物活性化合物.
研究的目的:
- 为了对 Dioscorea preussii.sii. 的上空部分进行植物化学调查.
- 从植物提取物中分离和表征化合物.
- 评估分离的化合物对抗氧化剂和尿酶抑制活性.
主要方法:
- 通过水性甲醇提取Dioscorea preussii的空气部件.
- 化学成分的分离和净化使用色谱技术.
- 通过光谱方法阐明分离化合物的结构,包括2D NMR.
- 在体外生物查抗氧化剂和尿酶抑制性质.
主要成果:
- 一种新型的酸盐,普鲁西酸 (1),与十种已知的化合物一起被分离出来:桑托米克罗尔 (2),胆-3-one (3),阿朱诺酸 (4),酸 (5),乌尔索酸 (6),贝图林 (7),卢皮醇 (8),p-hydroxybenzoic酸 (9),伊索瓦尼林 (10),和香草酸 (11).
- 化合物1,8 (lupeol) 和11 (香草酸) 具有强大的尿素酶抑制特性,IC50值分别为22.4,33.3和35.7μM. 化合物3 (胆-3-one) 显示中度活性.
- 化合物11 (香草酸) 在测试的分离物中表现出最强的抗氧化活性,IC50值为45.3μM.
结论:
- 对 Dioscorea preussii 的植物化学研究导致识别了新的和已知的化合物.
- 一些孤立的化合物,特别是普鲁西酸,卢皮醇和香草酸,具有显著的尿素酶抑制潜力.
- 香草酸表现出显著的抗氧化活性,表明其具有治疗意义.
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