在各种瘤微环境中,先天性淋巴细胞亚型2对免疫反应的编排,是癌症免疫治疗的合适目标
Rajdeep Roy1, Tanmoy Das2, Nabendu Biswas1
1Department of Life Sciences, Presidency University, Kolkata, India.
International reviews of immunology
|August 21, 2023
概括
天生的淋巴细胞亚型2 (ILC2) 在癌症免疫中起着双重作用. ILC 2可以促进抗瘤作用或创建抑制瘤的微环境,编排2型免疫.
科学领域:
- 免疫学 免疫学 免疫学
- 癌症生物学 癌症生物学
- 细胞生物学 细胞生物学
背景情况:
- 天生的淋巴细胞 (ILC) 是天生的免疫系统的关键调节者.
- 天生的淋巴细胞亚型2 (ILC2) 被公认为其在2型炎症反应中的作用以及参与各种人类恶性瘤.
- ILC 2 是一个关键的调节器,在瘤微环境 (TME) 中启动2型炎症反应.
研究的目的:
- 审查ILC2在癌症免疫中的功能.
- 总结最近关于ILC 2在不同癌症环境中的双重作用的科学发现.
- 阐明ILC 2调节对TME2型免疫的免疫反应的机制.
主要方法:
- 关于ILC2和癌症免疫力的最新科学研究的文献综述.
- 对ILC 2激活通路和下游细胞因子分泌的分析 (例如IL-4,IL-5,IL-13,IL-9).
- 检查TME中ILC 2与其他免疫细胞 (NK细胞,T细胞,MDSC,Treg细胞) 的相互作用.
主要成果:
- ILC 2的激活对于其在TME中的功能至关重要.
- 通过IL-33激活ILC2可以通过ILC-2/eosinophil轴调解抗瘤效应.
- 通过前列腺素D2 (PDG2) 介导的ILC2激活可以通过ILC-2/MDSC轴诱导一种免疫抑制的,亲瘤的位.
结论:
- ILC 2在癌症免疫中表现出双重作用,既起到抗瘤原生因素的作用,又起到促瘤原生因素的作用.
- 特定的激活途径和微环境背景决定了ILC 2在癌症中的功能.
- 在瘤微环境中,ILC2在调控2型免疫反应方面发挥着重要作用.
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