棕甲基乙醇胺通过重编程微生物群组成并影响托代谢来抵消高脂肪饮食引起的肠道功能障碍
Claudio Pirozzi1, Lorena Coretti1,2, Nicola Opallo1
1Department of Pharmacy, School of Medicine, University of Naples Federico II, Naples, Italy.
Frontiers in nutrition
|August 21, 2023
概括
在小鼠中补充棕甲基乙醇胺 (PEA) 可对抗肥胖引起的肠道失调和炎症. 皮埃重新平衡肠道微生物群和酸盐代谢,促进血清的产生和改善肠道功能.
科学领域:
- 胃肠病学 胃肠病学
- 神经科学是一个神经科学.
- 微生物学 微生物学
背景情况:
- 由高脂肪饮食 (HFD) 驱动的肥胖导致肠道失调和炎症,影响胃肠道 (GI) 和中枢神经系统 (CNS) 疾病.
- 作为内源性脂质调解剂的棕甲基乙醇胺 (PEA) 在治疗肠道和中枢神经系统疾病方面表现有前途,但其确切的机制尚不清楚.
研究的目的:
- 研究PEA对肠道炎症和由HFD诱导的肥胖引起的微生物群改变的影响.
- 阐明PEA发挥肠道保护和神经保护作用的机制.
主要方法:
- 给小鼠了一种HFD,并用超微缩PEA (30 mg/kg/天) 治疗了7周.
- 评估了炎症标志物,免疫细胞透,肠道微生物组成,以及结肠中的三-金氨酸代谢.
主要成果:
- PEA治疗减少了HFD诱导的肠道炎症和皮质otropin释放激素水平.
- PEA调节了托芬代谢,恢复了血清素 (5-HT) 循环,并降低了金氨酸.
- PEA重塑了肠道微生物群,增加了诸如Bifidobacterium和Turicibacter sanguinis等有益细菌,这些细菌与5-HT生产有关.
结论:
- 在小鼠中,PEA补充剂有效抵消HFD诱导的肠道失调和炎症.
- 通过重新平衡肠道微生物群和酸盐代谢,增强宿主血清生物合成和调节肠道功能来调节PEA的有益作用.
相关概念视频
Drugs for Treatment of Diarrhea-Predominant IBS
212
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
212
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
355
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
355
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists
303
Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
303
Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents
250
Diarrhea is characterized by the occurrence of frequent, watery bowel movements. Various factors can trigger diarrhea, including viral or bacterial infections, foodborne illnesses, side effects from certain medications, and underlying digestive disorders. If not adequately managed, diarrhea can lead to complications such as dehydration, electrolyte imbalances, and nutrient deficiencies. Severe diarrhea can lead to significant weight loss, malnutrition, and weakened immune function.
Adsorbents...
Adsorbents...
250
Drugs for Treatment of Constipation-Predominant IBS
206
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
206
Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents
246
Diarrhea, a condition marked by frequent loose or watery bowel movements, can be triggered by multiple factors such as viral or bacterial infections, food intolerances, anxiety, medications, and digestive disorders. Symptoms may include abdominal pain, bloating, nausea, and cramping. Severe or prolonged diarrhea can lead to complications like electrolyte imbalances, malnutrition, and dehydration if left untreated.
Opioids, widely used antidiarrheal agents, mitigate diarrhea by slowing down...
Opioids, widely used antidiarrheal agents, mitigate diarrhea by slowing down...
246


