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食品乳化剂对细胞功能和炎症的影响,一项初步研究

Beatrice Dufrusine¹, Chiara Di Lisio², Andrea Maurizio²

¹Department of Bioscience and Technology for Food Agriculture and Environment, University of Teramo, Teramo, Italy.

Frontiers in nutrition

|August 21, 2023

概括

常见的食物乳化剂 (EMs) 可能通过增加肠道细胞的增殖和迁移来促进肠道炎症. 这些乳化剂还增强炎症性细胞因子IL-6和CCL2的释放,激活巨细胞.

科学领域:

胃肠病学胃肠病学
细胞生物学细胞生物学
免疫学免疫学免疫学

背景情况:

乳化剂是广泛使用的食品添加剂,在西方国家越来越多的消费.
关于它们对肠道细胞功能和肠道炎症的影响的研究有限.

研究的目的:

研究常见的食品乳化剂 (EMI,EMII) 对肠道Caco-2细胞的影响.
为了比较乳化剂引起的细胞损伤与额外处女橄油 (EVOO).
在体外评估乳化剂的炎症潜力.

主要方法:

使用乳化剂 (EMI,EMII) 和EVOO处理Caco-2细胞.
用MTT和克隆基因试验评估了细胞活力.
细胞迁移通过伤口愈合试验进行评估.
分析了炎症标志物 (IL-6,CCL2) 和巨细胞激活.

主要成果:

乳化剂显著增加了Caco-2细胞的增殖和迁移率.
用乳化剂治疗导致IL-6和CCL2从Caco-2细胞中的释放增加.
来自乳化剂处理的细胞的条件介质激活了巨细胞.

结论:

初步数据表明,乳化剂可以作为促炎分子.
乳化剂可能通过增加细胞增殖,迁移和细胞因子释放,导致肠道炎症.
需要进一步的研究来了解乳化剂消费的临床影响.

关键词:

在Caco-2细胞中.细胞因子细胞因子额外处女橄油橄油食品乳化剂食品乳化剂巨细胞激活的激活

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