维生素D缺乏与中风后抑郁症的关联:来自美国TriNetX协作网络的回顾性队列研究
Chun-Ning Ho1,2,3, Cheuk-Kwan Sun4,5, Jheng-Yan Wu6
1Department of Anesthesiology, Chi Mei Medical Center, Tainan City, Taiwan.
Frontiers in nutrition
|August 21, 2023
概括
在这项研究中,维生素D缺乏 (VDD) 与中风后抑郁症 (PSD) 的更高风险无关. 需要进一步的研究来确认维生素D是否提供对PSD的保护作用.
科学领域:
- 神经学 神经学
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 脑卒中后抑郁症 (PSD) 影响了大量的中风幸存者.
- 维生素D缺乏 (VDD) 是一种常见的疾病,具有潜在的全身影响.
- 调查VDD和PSD之间的联系对于理解中风恢复至关重要.
研究的目的:
- 检查维生素D缺乏 (VDD) 与中风后抑郁症 (PSD) 的风险之间的联系.
- 评估VDD与包括肺炎和急诊室访问在内的二次结果之间的关系.
- 在匹配的队列研究中,使用倾向性得分匹配来调整混因素.
主要方法:
- 如果在中风前3个月内可获得维生素D水平,则将首次中风的成年患者纳入.
- 患者被分为VDD (<20 ng/mL) 和正常维生素D (30-80 ng/mL) 组.
- 倾向性得分匹配 (PSM) 用于在不同组之间平衡基线特征.
主要成果:
- 在3个月 (5.8%对4.7%) 和12个月 (11.6%对10.2%) 的随访期间,在VDD和对照组之间没有观察到PSD发病率的显著差异.
- 在任何随访时间点 (3个月HR=1.258;12个月HR=1.210) 中,VDD与PSD风险增加无关.
- 12个月后,VDD并没有显著增加肺炎或急诊室访问的风险.
结论:
- 这项研究发现,维生素D缺乏与中风后抑郁症的风险之间没有显著的关联.
- 这些发现表明,VDD可能不是PSD风险的主要贡献者.
- 建议进行进一步的前性研究,以探索维生素D在中风后恢复中的潜在保护作用.
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