在慢性血液透析患者中对COVID-19疫苗接种的抗体反应
Heejung Choi1, Sungdam Han2, Ji Su Kim3
1Department of Nephrology, Ajou University School of Medicine, Suwon, Korea.
Clinical and experimental vaccine research
|August 21, 2023
概括
血液透析患者的COVID-19疫苗接种显示出持续至少6个月的显著抗体反应. 这项研究评估了亚洲血液透析患者的疫苗有效性,发现疫苗接种后抗体水平持续.
科学领域:
- 免疫学 免疫学 免疫学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 传染性疾病 传染性疾病
背景情况:
- 接受血液透析 (HD) 的患者患COVID-19的风险增加.
- 之前关于COVID-19疫苗在HD患者中的有效性研究主要集中在西方人群中.
研究的目的:
- 评估亚洲血清透析患者的抗体反应和COVID-19疫苗有效性的持续时间.
- 为了比较血液透析患者和健康志愿者之间的抗体反应.
主要方法:
- 在HD患者 (n=39) 和健康对照组 (n=22) 中比较免疫球蛋白G (IgG) 和中和抗体水平.
- 在不同时间点测量抗体,最多在ChAdOx1 nCoV-19或mRNA-1273疫苗第二剂后6个月.
- 分析了第三剂疫苗和年龄,性别,BMI和免疫抑制等因素对抗体反应的影响.
主要成果:
- 在接种两剂疫苗后,HD患者的IgG和中和抗体增加,尽管比对照体弱.
- 在接种疫苗后的6个月内,抗体水平保持稳定,随着时间的推移没有显著下降.
- 更高的BMI与更好的血清反应相关,而免疫抑制与HD患者的反应较差有关.
结论:
- 两剂COVID-19疫苗诱导血液透析患者显著和持久的抗体反应.
- 在HD患者中,抗体反应在接种疫苗后至少持续了6个月.
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