确定主要抑郁症障碍的循环生物标志物
En Zhang1, Zhongfei Huang1, Zongjun Zang1
1Department of Psychiatry, The Fourth People's Hospital of Wuhu City, Wuhu, China.
Frontiers in psychiatry
|August 21, 2023
概括
六种循环蛋白质,包括胰岛素和Lipocalin-2,显示为生物标志物,用于诊断主要抑郁症 (MDD) 和评估症状严重程度.
科学领域:
- 生物标志物发现发现
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
背景情况:
- 目前的主要抑郁症 (MDD) 诊断依赖于临床症状,导致误诊和无效治疗.
- 对于MDD的客观诊断生物标志物有着至关重要的需求.
研究的目的:
- 识别和验证用于诊断MDD的循环蛋白质生物标志物.
- 探索已识别的生物标志物与抑郁症严重程度之间的相关性.
主要方法:
- 使用高通量抗体阵列技术分析了MDD患者和健康对照组中的440种循环细胞因子.
- 拉索回归确定了特征性蛋白质,这些蛋白质使用酶相关免疫吸收试验 (ELISA) 进行了验证.
- 接收器操作特征 (ROC) 曲线分析评估了诊断值,线性回归评估了与HAMD-17分数的相关性.
主要成果:
- 发现59种蛋白质在MDD患者中表达不同.
- 六种蛋白质 (胰岛素,CD40L,CD155,Lipocalin-2,HGF,LIGHT) 通过LASSO回归进行了选择.
- 在对MDD患者进行区分的ROC分析中,这些六种蛋白质的曲线下面面积 (AUC) 超过0.85,胰岛素,CD155,Lipocalin-2,HGF和LIGHT与抑郁症严重程度相关 (HAMD-17得分).
结论:
- 鉴定到的六种特征性蛋白质显示出MDD的诊断生物标志物的潜力.
- 胰岛素,CD155,Lipocalin-2,HGF和LIGHT可以作为评估MDD抑郁症状严重程度的指标.
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