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Updated: Jul 18, 2025

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
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基于生理学的药理动力学模型来预测健康和疾病人群中metoprolol的处置

Ammara Zamir1, Muhammad Fawad Rasool1, Imran Imran2

  • 1Department of Pharmacy Practice, Faculty of Pharmacy, Bahauddin Zakariya University, Multan 60800, Pakistan.

ACS omega
|August 21, 2023
PubMed
概括

开发了基于生理学的药理动力学 (PBPK) 模型,以评估健康个体和慢性脏病 (CKD) 或急性心肌梗塞 (AMI) 患者的美托普罗罗尔PK. 这些模型准确地预测了PK变化,有助于优化患病人群的剂量.

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