尿道支架生物材料的比较:在石质人造尿模型中的层配置
Yi X Wu1, Eric J Choi2, Amberly A Vu1
1Department of Urology, University of California, Irvine, Orange 92868, California, United States.
ACS omega
|August 21, 2023
概括
用HEMA涂层的Pellethane是一种用于尿管支架的有前途的生物材料,在人工尿中显示出显著的层. 黑色支架表现最好,表明它们在泌尿器科应用中长期使用的潜力.
科学领域:
- 生物材料科学 生物材料科学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 聚合物化学 聚合物化学
背景情况:
- 尿道支架层限制了停留时间,并导致泌尿器科问题.
- 目前没有理想的聚合物生物材料能够抵抗长期的尿液暴露.
- 涂有2-乙基甲基酸盐 (HEMA) 的烯最近被认为是一种有前途的耐化生物材料.
研究的目的:
- 为了比较HEMA涂层的Pellethane与商业上可用的尿路支架的抗性.
- 评估HEMA涂层颗粒和其他支架材料上的层的程度和组成.
- 评估HEMA涂层颗粒物和其他材料对长期尿路支架的适用性.
主要方法:
- 一个批量流模型使用两个人造尿液溶液 (AUS) 在37°C下11周.
- 定期更换AUS用新鲜的部件,使用环静电系统.
- 扫描电子显微镜 (SEM) 用于层度和感应合等离子体质谱 (ICP-MS) 用于元素组成 (Ca,Mg,P).
主要成果:
- 在11周后,HEMA涂层的Pellethane表现出最大的平均质量变化.
- 在AUS.M中,SEM在2周内揭示了HEMA涂层的Pellethane在2周内完全化.
- ICP-MS确定 (Ca) 是最丰富的沉积物;黑色支架表现出卓越的性能.
结论:
- 由于迅速和广泛的层,HEMA涂层的颗粒材料不是尿路支架的理想材料.
- 基尿路支架,特别是黑色,显示出改善长期内存性能的显著前景.
- 对先进的材料的进一步研究可能会导致改善尿路支架设计,减少层.
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