对听觉-肠-大脑轴的审查
Amy S Graham1,2, Benneth Ben-Azu3,4, Marie-Ève Tremblay3,5,6,7,8,9,10
1Imaging Sciences, Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Frontiers in neuroscience
|August 21, 2023
概括
这篇评论探讨了肠-大脑轴如何影响听力. 它确定了解剖学,免疫和饮食的联系,建议治疗听力损失的新途径.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 听力损失是一个重大的全球健康负担,影响生活质量.
- 肠-大脑轴在各种疾病中建立,但其与听觉系统的联系尚未得到充分探索.
研究的目的:
- 审查连接听觉系统和肠-大脑轴的潜在机制.
- 通过解剖学,细胞外,免疫和饮食领域识别听觉-肠-大脑轴的关键参与者.
主要方法:
- 使用PubMed和谷歌学者以有针对性的关键词进行文献评论.
- 综合发现分为解剖学,细胞外,免疫和饮食方面.
主要成果:
- 迷走神经提供了听觉系统和肠-大脑轴之间的直接解剖联系.
- 免疫反应和饮食显著影响肠道微生物群,并可能影响听力健康.
- 细胞外信号通路提供了耳朵,肠道和大脑之间的潜在通信路线.
结论:
- 几个关键的参与者和机制可能将听觉系统与肠-大脑轴联系起来.
- 需要在动物模型和人体研究中进行进一步的研究来验证这些联系.
- 了解听觉-肠-大脑轴可能会导致听力损失治疗的新干预措施.
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