间歇性能量限制改变了肥胖的人类大脑的区域同质性
Zhonglin Li1, Xiaoling Wu2, Hui Gao3
1Department of Radiology, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Henan University People's Hospital, Zhengzhou, China.
Frontiers in neuroscience
|August 21, 2023
概括
间歇性能量限制 (IER) 通过改变大脑活动,改善代谢健康,减少肥胖成年人的进食冲动性,有效地帮助减肥. 这项神经成像研究揭示了IER.
科学领域:
- 神经科学是一个神经科学.
- 代谢健康 代谢健康
- 肥胖问题研究研究
背景情况:
- 间歇性能量限制 (IER) 是一种公认的减肥策略.
- IER对自发神经活动的影响及其与代谢标记物的相关性仍然不清楚.
- 在IER期间的人类测量,生化和阿迪波金变化之间的关系需要进一步阐明.
研究的目的:
- 研究2个月的IER干预对大脑活动的影响,特别是区域同质性 (ReHo).
- 检查ReHo变化之间的相关性,人体测量测量,生化指标和阿迪波金 (莱普丁,阿迪波内克丁).
- 探索IER在肥胖个体体重管理中的有效性的神经生物学基础.
主要方法:
- 招募了35名肥胖成年人参加为期2个月的IER干预.
- 在四个时间点收集了人类测量,血液样本和休息状态功能磁共振成像 (fMRI) 的数据.
- 利用区域同质性 (ReHo) 方法分析fMRI数据并评估自发神经活动的变化.
主要成果:
- 在成功减肥的参与者中,IER显著改善了人体测量,生化指标和阿迪波金水平.
- IER干预导致双边语言,左和左后中心的ReHo增加,右中旋和右小脑的ReHo减少.
- 在右舌环和左骨中增加的ReHo与降低的TFEQ抑制相对应,与增加的TFEQ认知控制相对应.
结论:
- IER干预在肥胖个体的特定大脑区域重塑ReHo,与改善的代谢和人类标志物相关联.
- IER可以通过减少饮食动机,调节对食物提示的奖励反应,增强自我控制来促进减肥.
- 这些发现提供了神经生物学证据,支持IER作为肥胖的减肥策略.
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