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在患有食道癌的患者中,泛免疫炎症的价值和预后
Yoshifumi Baba1,2, Shigeki Nakagawa1, Tasuku Toihata1
1From the Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
概括
全免疫炎症值 (PIV) 是食道癌的预后生物标志物,与存活率和瘤免疫力相关. 较高的PIV表明结果较差,瘤透淋巴细胞减少,这表明系统性免疫影响预后.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 癌症研究 癌症研究
背景情况:
- 全免疫炎症值 (PIV) 是癌症预后的新标志物,但其在食道癌症中的重要性尚未得到充分证实.
- 食道癌的预后受到各种因素的影响,包括瘤微环境和全身免疫状态.
研究的目的:
- 在患有食道癌的患者中调查泛免疫炎症值 (PIV) 的预后值.
- 探索PIV,瘤免疫 (包括瘤透淋巴细胞和CD8表达) 和临床结果之间的关系.
主要方法:
- 一个导出队列 (n=433) 使用ROC曲线确定了最佳PIV切线.
- 一个验证队列 (n=433) 评估了PIV与整体存活率,瘤透淋巴细胞 (TILs) 和CD8表达的关联.
- 免疫组织化学染色被用于评估CD8表达.
主要成果:
- PIV在食道癌症中表现出预后能力,较高的PIV与明显较差的整体存活率相关 (HR: 1.41,P=0.023).
- 升高的PIV与较低的TILs (P<0.001) 和降低的CD8阳性细胞计数 (P=0.011) 有显著的相关性.
- PIV的预后影响独立于其他临床特征.
结论:
- 全免疫炎症值 (PIV) 作为食道癌的宝贵预后生物标志物.
- PIV与瘤免疫有关,这表明系统性免疫状态通过局部免疫反应影响患者的预后.
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