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聚多巴胺修饰的Ceria纳米棒通过清除ROS和调节巨细胞M2极化来缓解结肠炎的炎症

Bingqing Zhang¹, Qiang Li¹, Qinglin Xu¹

¹Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, People's Republic of China.

International journal of nanomedicine

|August 21, 2023

概括

这项研究引入了CeO2@PDA-PEG纳米颗粒,用于对抗炎症性肠病 (IBD) 中的氧化应激. 这些纳米粒子有效地清除反应性氧物种 (ROS) 并减少结肠炎症,为IBD提供了有前途的治疗策略.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
免疫学免疫学免疫学

背景情况:

炎症性肠病 (IBD) 与细胞内氧化应激增加有关.
开发新的策略来中和反应性氧物种 (ROS) 对于控制IBD中的结肠炎症至关重要.

研究的目的:

为了合成和表征CeO2@PDA-PEG (CeO2@PP) 纳米颗粒用于ROS清理和抗炎应用.
在小鼠模型中评估CeO2@PP在治疗硫酸盐 (DSS) 诱导的大肠炎中的疗效.

主要方法:

使用聚多巴胺 (PDA) 和聚乙烯糖醇 (PEG) 修改了CeO2纳米棒,以形成CeO2@PP纳米粒子.
通过流动细胞计和共聚焦激光扫描显微镜来评估ROS清理活动.
在体外的抗炎作用被研究在脂聚糖 (LPS) 刺激的RAW 264.7巨细胞中.
生物相容性在体外和体内进行了评估,治疗效果在DSS诱导的大肠炎小鼠模型中进行了测试.

主要成果:

由于PDA和PEG的修饰,CeO2@PP纳米粒子表现出增强的分散性和体稳定性.
这些纳米颗粒显示出显著的类似酶的活性 (超氧化物转化酶和转化酶),这表明它们具有强大的抗氧化能力.
实验室研究表明,CeO2@PP促进了M2型巨细胞的两极分化,并且具有出色的生物相容性和生物安全性.
在体内实验证实,CeO2@PP在DSS诱导的大肠炎模型中有效缓解肠粘膜损伤和炎症.

结论:

CeO2@PP纳米平台显示出显著的抗氧化和抗炎性质.
这些纳米粒子有效地清除ROS并调节巨细胞两极分化,显示大肠炎治疗的前景.

关键词:

在 PDA 和 PDA 之间.这是一种抗炎症药物.抗氧化作用抗氧化作用这里是CeriaCeria.大肠炎是一种大肠炎.巨细胞的两极分化纳米酶纳米酶是一种纳米酶.

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