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亚斯巴酸盐和酸盐燃料胃肠道流体瘤超越华堡效应

Ying-Chieh Lai^1,2, Gigin Lin^1,2, Kung-Chu Ho³

¹From the Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linko, Chang Gung University, Taoyuan, Taiwan.

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|August 21, 2023

概括

胃肠道 stromal 瘤 (GISTs) 呈现出明显的代谢特征,其中阿斯巴酸被确定为关键的代谢因子. 了解这些代谢漏洞对于开发针对GIST的向疗法至关重要.

科学领域:

在瘤学瘤学.
代谢学代谢学代谢学
生物化学生物化学

背景情况:

代谢重编程是癌症的标志性特征,显著影响胃肠道 stromal 瘤 (GIST) 的瘤发生和耐药性.
识别GIST中的特定代谢途径和脆弱性对于开发有效的治疗策略至关重要,特别是在耐火病例中.

研究的目的:

为绘制未经治疗的GISTs的代谢景观.
确定与GISTs不同风险分层相关的关键代谢变化.
在GIST中探索糖解,乙酸代谢和脂肪酸合成之间的相互作用.

主要方法:

一组43名以前没有接受过治疗的GIST患者接受了手术切除.
使用1H核磁共振 (NMR) 进行了手术样本的代谢学分析.
分析了关键代谢酶 (GLUT1,HK2,ACSS2,FASN) 的mRNA和蛋白质水平,同时对15名患者进行了双追踪器PET成像 (18F-FDG/11C-乙酸盐).

主要成果:

GISTs显示了高调的谷氨酸,甲酸盐,酸盐和甘氨酸,与低调的胆,肌酸,葡萄糖和甘油.
确定TCA循环和阿拉宁,阿斯巴酸和谷氨酸代谢是主要的代谢途径.
高风险的GIST表现出更高的HK2和18F-FDG吸收,而非高风险的GIST显示出更高的ACSS2和11C-酸盐吸收,表明这些途径的互补作用.

结论:

酸作为GIST中的代谢物,由TCA循环和相关的代谢途径维持.
糖解和ACSS2介导的酸盐代谢是GIST中脂肪酸合成的竞争性但互补的途径.
糖解与GISTs中的侵略性表型有关.

关键词:

在TCA循环中,TCA循环是华堡效应是什么? 华堡效应乙酸乙烯的使用方法亚斯巴酸盐是一种胃肠道 stromal 瘤的发生.代谢生物组的代谢生物组

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