聚合物纳米细胞的近期发展,用于治疗眼睛疾病
Ruijun Cai1, Ling Zhang1, Hao Chi2
1Department of Pharmacy, The People's Hospital of Jiuquan, Jiuquan, Gansu, China.
Frontiers in bioengineering and biotechnology
|August 21, 2023
概括
聚合物微粒提供先进的眼部药物输送,克服持续药物治疗的眼睛障碍. 本综述涵盖了2014-2023年纳米细胞眼睛治疗的创新和临床挑战.
科学领域:
- 眼科医生 眼科 眼科
- 纳米技术 纳米技术
- 材料科学 材料科学 材料科学
背景情况:
- 眼睛拥有复杂的屏障和清除机制,需要先进的药物输送系统.
- 聚合物微粒已经成为眼部药物的有前途的纳米配送平台.
- 创新包括poloxamer,chitosan,水凝封装,和隐形眼镜嵌入的微粒.
研究的目的:
- 从2014年到2023年,巩固基于聚合物纳米细胞的眼部药物输送方面的进展.
- 探索与这些纳米细胞的临床应用相关的挑战.
- 为指导眼部药物输送配方设计的未来研究.
主要方法:
- 关于聚合物纳米细胞眼部药物递送系统的综合文献综述.
- 分析微粒组合和配方方面的创新 (例如,波洛克萨默,奇托桑,水凝,隐形眼镜).
- 检查临床应用挑战和未来研究方向.
主要成果:
- 聚合物微粒可使药物持续保留并在眼睛内增强透.
- 已经开发出多种纳米细胞平台,包括poloxamer,chitosan,水凝封装和隐形眼镜嵌入的小细胞.
- 在过去的十年里,眼部药物输送技术取得了重大进展.
结论:
- 聚合物纳米细胞代表了眼部药物输送的前沿方法.
- 解决临床应用挑战对于这些技术的成功转化至关重要.
- 未来的研究应该专注于优化纳米细胞配方,以改善眼部治疗结果.
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