SHP2与癌症的发生,发展和预后有关
Shu Li1,2, Jialing Qu1,2, Xiaotong Wang3,4
1Department of Clinical Laboratory, Women and Children's Hospital of Chongqing Medical University, Chongqing 401174, P.R. China.
Oncology letters
|August 21, 2023
概括
含有Src同质-2域的蛋白质氨酸酸酶 (SHP2) 影响固体瘤的进展和预后. 虽然增加的SHP2对某些癌症有好处,但它会使其他癌症的结果恶化,这表明它是潜在的治疗点.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 免疫学 免疫学 免疫学
背景情况:
- 由PTPN11编码的Src同质-2域含有蛋白质氨酸酸酶 (SHP2),在细胞信号和疾病中至关重要.
- SHP2在固体瘤发育,进展和患者预后方面的作用需要全面调查.
研究的目的:
- 评估SHP2表达对各种固体瘤的发生,发展和预后的影响.
- 探索SHP2与瘤微环境,免疫细胞透和瘤突变负担之间的关联.
主要方法:
- 来自癌症基因组图谱 (TCGA) 的转录组测序数据用于33种癌症类型.
- 生物信息分析包括生存分析 (日志排名,考克斯回归),估计,CIBERSORT和斯皮尔曼相关性.
- 在特定癌症患者的外周血液样本中检测SHP2表达的ELISA.
主要成果:
- 在许多瘤组织中,SHP2表达升高,与瘤进展和预后相关.
- 在不同癌症类型中,SHP2的预后值有很大差异;它改善了脏清细胞癌的存活率,但减少了尿路细胞癌,宫/宫内,乳腺侵入性癌,中瘤和肝肝细胞癌的存活率.
- SHP2表达与瘤微环境相关,影响T细胞和M2巨细胞激活,并与瘤突变负担和微卫星不稳定性相关.
结论:
- 在固体瘤的进展和患者的结果中,SHP2起着复杂的,取决于背景的作用.
- SHP2表达水平可以作为各种癌症的预后生物标志物.
- SHP2代表了癌症治疗的有前途的治疗标,需要进一步研究.
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