在健康参与者中对不同配方奎尔塞丁的药理动力学研究:饮食控制,交叉,单剂和多剂试点研究
Julia Solnier1, Yiming Zhang1, Kyle Roh1
1ISURA, Burnaby, BC V3N4S9, Canada.
利波米塞尔 (LipoMicel®) 显著提高了人类的氨酸吸收,与标准氨酸相比,500mg的吸收增加了7倍,1000mg的吸收增加了15倍. 这种增强的生物可用性可能会改善奎尔丁的健康益处.
科学领域:
- 营养科学 营养科学
- 药理动力学 药理动力学
- 人类生理学 人类生理学
背景情况:
- 奎尔赛丁是一种广泛研究的黄类化合物,表现出各种促进健康的特性.
- 标准氏素的口服生物可用性较差限制了其治疗潜力.
- 需要新的输送系统来增强奎尔丁的吸收和疗效.
研究的目的:
- 为了评估不同配方的管理后奎尔塞丁的药理动力学特征.
- 在健康的成年人中,比较标准氨酸与LipoMicel® (LM) 的生物可用性.
- 为了评估单次和多次剂量LM后的奎尔塞丁血度和代谢物概况.
主要方法:
- 一项随机,交叉,饮食控制的试点研究,涉及10名健康成年人.
- 在标准配方和LM配方中,单剂和多剂口服quercetin aglycone (250mg,500mg,1000mg) 的使用.
- 在72小时内测量血度 (AUC0-24,Cmax) 和代谢物分析.
主要成果:
- 与标准Quercetin相比,LipoMicel®显著增加了血中的Quercetin度的7倍 (500mg LM) 和15倍 (1000mg LM).
- 即使用了一半的剂量 (250mg LM),奎思的吸收率也大约是标准奎思的3倍.
- 检测到奎尔塞丁代谢物 (甲基化,硫酸盐,GSH合物) 长达72小时,其度有显著差异.
结论:
- 补充LipoMicel®是一种有前途的策略,可以增强奎尔西丁的吸收,并可能对人类的健康有益.
- 由LM证明的改善生物可用性需要在更大的种群中进一步研究.
- 需要进一步的研究来证实这些发现,并探索增强氨酸输送的临床影响.
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