编程死亡的评估 - - 头部和部状细胞癌中的干1 (Pd-L1) 表达
Aarya Unnikrishnan1, Vijaya Basavaraj1
1Department of Pathology, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.
Iranian journal of pathology
|August 21, 2023
概括
编程死亡联体-1 (PD-L1) 在头部和部状细胞癌 (HNSCC) 中高度表达. PD-L1表达与瘤透的淋巴细胞相关,这表明免疫治疗患者选择的潜力.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 病理学 病理学 病理学
背景情况:
- 头部和部状细胞癌 (HNSCC) 的预后不好,五年生存率低于50%.
- 抗PD-L1免疫疗法对HNSCC治疗具有前景.
- 免疫组织化学 (IHC) 对于免疫治疗患者的分层至关重要.
研究的目的:
- 评估HNSCC中编程死亡-1 (PD-L1) 表达的预后意义.
- 确定PD-L1表达与HNSCC.临床病理变量之间的关联.
主要方法:
- 研究了50例活检确认的HNSCC病例.
- 使用IHC与抗体克隆CAL-10进行PD-L1表达的评估.
- 通过综合阳性得分 (CPS) 和分析的关联得分的PD-L1表达.
主要成果:
- 在92%的HNSCC病例中检测到PD-L1表达.
- 在PD-L1表达和瘤透淋巴细胞 (TILs) (P=0.024) 之间观察到显著的关联.
- 在PD-L1表达和患者人口统计学,瘤部位,等级或阶段之间没有发现显著的关联.
结论:
- 在HNSCC中PD-L1表达的高患病率,特别是在具有TILs的瘤中.
- PD-L1 IHC是选择HNSCC患者接受免疫治疗的有希望的方法.
- PD-L1表达可能有助于确定可以从抗PD-1/PD-L1治疗中受益的患者.
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