是导致失脂症的可能原因
Archana Gaur1, Prasunpriya Nayak2, Sutirtha Ghosh2
1Department of Physiology, All India Institute of Medical Sciences, Bibinagar, Hyderabad, Telangana, India.
Indian journal of occupational and environmental medicine
|August 21, 2023
概括
暴露会破坏细胞能量产生和脂质代谢,导致不脂血症,这是非传染性疾病的危险因素. 这篇评论探讨了的价值.
科学领域:
- 生物化学 生物化学
- 环境健康 环境健康
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 在日常产品中无处不在,导致人类不可避免的暴露.
- 暴露与神经退行有关,但其在失脂症中的作用未得到充分研究.
- 脱脂症是全球主要的健康问题,有助于非传染性疾病.
研究的目的:
- 研究将暴露与失脂症相关联的生物化学机制.
- 提供对脂质代谢的影响的全面概述.
- 为了突出作为潜在的因素在失脂症的发展.
主要方法:
- 在四个医学数据库中进行文献搜索.
- 遵守PRISMA系统审查指南.
- 分析受影响的生物化学途径.
主要成果:
- 会干扰能源生产中的依赖铁的酶 (TCA循环,电子传输链).
- 线粒体功能障碍,氧化应激和脂质过氧化是由引起的.
- 通过α-甲酸,L-卡尼丁和雌激素受体通路调节脂质代谢.
- 呼吸链的破坏和改变的糖解有助于脂肪积累和肝脏疾病.
结论:
- 暴露会扰乱线粒体功能和脂质代谢,导致脂质失调.
- 作为一种金属雌激素,影响脂质配置和炎症.
- 工业化和城市化可能会增加与引起的脂质失调症相关的风险.
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