相关实验视频

Updated: Jul 18, 2025

Identification and Dissection of Diverse Mouse Adipose Depots

Identification and Dissection of Diverse Mouse Adipose Depots

Published on: July 11, 2019

在患有甲状腺眼病的患者中,轨道脂肪组织的代谢特征

Rui Du¹, Fenfen Wang^2,3, Chun Yang^2,3

¹Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Frontiers in endocrinology

|August 21, 2023

概括

甲状腺眼睛疾病 (TED) 涉及过多的轨道脂肪积累. 我们的研究确定了这种脂肪中的关键代谢差异,为TED患者提供了潜在的新治疗点,超出了手术范围.

科学领域:

眼科医生眼科眼科
代谢学代谢学代谢学
内分泌学在内分泌学.

背景情况:

甲状腺眼病 (TED) 是成年人最常见的轨道疾病,其特点是轨道脂肪组织 (OAT) 积累.
积累OAT可能导致眼收缩和视力丧失,手术是不活动TED的主要治疗方法.
目前治疗的局限性源于对TED病变的不完全理解,特别是其代谢方面的理解.

研究的目的:

在TED患者中研究OAT的代谢物含量和特征.
通过了解其潜在的代谢特征来确定TED的潜在新型治疗点.

主要方法:

轨道脂肪组织 (OAT) 样本从7名非活动TED患者和5名对照患者中收集.
用液体染色学-质谱法测量了代谢物概况.
进行了差异代谢物分析和途径丰富分析.

主要成果:

总共检测到149个代谢物概况,在TED和对照组之间观察到显著差异.
关键的分化代谢物包括尿酸,氧化谷氨,牛和 uracil (p < 0.05).
确定了与TED相关的途径,包括精氨酸代谢,β-氨酸代谢和谷氨代谢 (p < 0.05).

结论:

这项研究阐明了TED患者中OAT的独特代谢特征.
研究结果表明,TED有可能成为新的治疗目标,为外科手术提供替代方案.
已识别的代谢物和途径为开发TED的新型非手术治疗提供了基础.

关键词:

代谢特征代谢特征代谢特征轨道脂肪组织组织.病变的发生和发病.甲状腺眼睛疾病甲状腺眼睛疾病治疗目标治疗目标

更多相关视频

Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots

Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots

Published on: August 16, 2020

Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator

Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator

Published on: May 19, 2023

相关概念视频

The Thyroid Gland

The Thyroid Gland

The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...

Functions of Thyroid Hormones

Functions of Thyroid Hormones

The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...

Synthesis and Regulation of Thyroid Hormones

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...

Hypodermis

Hypodermis

The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...