评估骨矿物质密度和骨周转率在儿童使用抗凝药
Katharina Thom1, Janina Maria Patsch2, Florentina Haufler3,4
1Division of Pediatric Cardiology and Haemostaseology, Department of Pediatric and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.
Frontiers in endocrinology
|August 21, 2023
概括
接受抗凝药 (AC) 的儿童可能会出现骨矿物质密度 (BMD) 降低. 低体重指数 (BMI) 和青春期是关键的危险因素,强调需要监测骨健康在这一群体.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 骨的新陈代谢 骨的新陈代谢
- 药理学 药理学是指药理学的学科.
背景情况:
- 童年和青春期对于骨矿物质的获得至关重要.
- 接受抗凝药 (AC) 的儿童可能面临骨矿物质密度 (BMD) 降低的风险.
- 诸如慢性疾病,不运动以及某些药物等因素会影响骨发育,而维生素K (VK) 缺乏与骨质疏松症有关.
研究的目的:
- 在接受AC的儿科患者中评估BMD.
- 确定与低骨质量相关的危险因素,包括维生素K (VK) 和维生素D (VD) 状态.
主要方法:
- 一个单中心,横截面研究,涉及临床,生化和密度测量评估.
- 使用替代标记物,如低碳氧化骨素 (ucOC) 和矩阵格拉蛋白 (MGP),评估VK状态.
主要成果:
- 研究了39名接受AC治疗的儿童 (4-18岁);31名接受VK抗剂,8名接受直接口服抗凝剂.
- 在腰椎 (-0.7SDS) 和全身减去头部 (-1.32SDS) 观察到 BMD 减少.
- 早期青春期发育与TBLH-BMD相关,BMI与LS-BMD相关;与年龄和青春期相关的VK标志物;10/39例患者患有VD缺乏症,在青春期更为普遍.
结论:
- 在AC治疗的儿科患者表现出减少的BMD.
- 低BMI和青春期阶段是 BMD 减少的重要危险因素,而不是 AC 相关的因素.
- 提高对这些风险因素的认识,以及青春期高发性静脉疾病缺陷,对于改善这个脆弱群体的骨健康至关重要.
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