胸膜重聚也与非空间记忆的巩固有关
Jennifer J Hamilton1,2,3, John C Dalrymple-Alford1,2,3,4
1School of Psychology, Speech and Hearing, University of Canterbury, Christchurch, New Zealand.
Frontiers in behavioral neuroscience
|August 21, 2023
概括
核团聚 (RE) 在远程非空间记忆回忆中发挥作用. 这种中线 thalamus 结构对于超越空间任务的记忆巩固至关重要.
科学领域:
- 神经科学是一个神经科学.
- 记忆研究 记忆研究
- 胸膜功能 胸膜功能
背景情况:
- 在中线 thalamus 中的核团聚 (RE) 连接海马和前额皮层.
- 这种解剖学联系表明它在记忆巩固中的作用,但证据仅限于空间和上下文恐惧记忆.
研究的目的:
- 调查核团聚 (RE) 是否参与远程非空间记忆回忆.
- 确定RE的功能是否超出了空间和恐惧记忆中的既定角色.
主要方法:
- 长埃文斯老鼠被训练在一个气味-痕迹-对象配对-关联任务与10秒的延迟.
- 在RE中测量了即时早期基因 (Zif268) 表达,在获取后的不同时间点和远程回忆后.
- 在中部前额皮质 (mPFC) 中的IEG表达也被评估.
主要成果:
- 与较短的回忆间隔和对照组相比,RE中的神经元在测试远程非空间记忆的老鼠 (25天后获得) 中显著增加了Zif268激活.
- 在远程召回组中,在中间PFC (前带皮层和前皮层) 的表面层中观察到增强的IEG表达.
结论:
- 核团聚 (RE) 在远程召回非空间记忆时优先参与.
- 这些发现扩大了RE已知的功能曲目,超越了空间记忆和上下文恐惧记忆.
相关概念视频
Role of Hippocampus in Memory
312
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
312
Higher Mental Functions of Brain: Learning and Memory
871
Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...
871
Role of Neurotransmitters in Memory
627
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
627
Diencephalon: Thalamus and Information Relay
1.7K
The thalamus, often called “the gateway to the cerebral cortex,” is vital in processing and directing sensory and motor signals throughout the brain. Almost all inputs destined for the cerebral cortex, except for olfactory signals, are relayed through the thalamus. The thalamus is a sophisticated relay station, channeling information from various brain regions to the cerebral cortex, as well as a filter, prioritizing certain signals over others based on current physiological...
1.7K
Long-term Potentiation
2.8K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
Hebbian LTP
LTP can occur when...
2.8K
Association Areas of the Cortex
5.5K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
5.5K


