EMT转录因子在血液病发育和恶性瘤中的"意想不到"的作用
Karthika Radhakrishnan1, Lynda Truong1, Catherine L Carmichael1,2
1Centre for Cancer Research, Hudson Institute of Medical Research, Clayton, VIC, Australia.
Frontiers in immunology
|August 21, 2023
概括
像ZEB,TWIST和SNAIL这样的表皮细胞转移到介质细胞的转录因子 (EMT-TF) 在发育和癌症中至关重要. 在正常的血细胞发育和血液癌症中的意想不到的作用现在正在成为潜在的治疗点.
科学领域:
- 分子生物学分子生物学
- 发展生物学 发展生物学
- 血液学 血液学 血液学
背景情况:
- 表皮转移到介质细胞转移 (EMT) 对胚胎发育和癌症转移等病理过程至关重要.
- 来自ZEB,TWIST和SNAIL家族的EMT转录因子 (EMT-TF) 是EMT的关键调节者.
- 最近的发现揭示了EMT-TF在血液形成中的新功能,独立于经典的EMT.
研究的目的:
- 审查ZEB,TWIST和SNAIL家族在EMT中的既定角色.
- 探索EMT-TFs在正常血细胞发育 (血液形成) 中的新兴和意想不到的功能.
- 讨论EMT-TFs在血液性恶性瘤的发病过程中的参与及其治疗潜力.
主要方法:
- 对EMT转录因子研究的文献综述.
- 对血液形成和血液癌症发展的研究分析.
- 综合有关EMT-TF调节和功能的当前知识.
主要成果:
- 在正常的胚胎发育和癌症进展中,EMT-TF发挥着至关重要的作用.
- 在正常的血细胞发育中,EMT-TF表现出以前未被识别的功能.
- EMT-TFs与白血病和淋巴瘤的发展和进展有关.
结论:
- 除了经典的EMT外,EMT转录因子具有不同的作用,包括在血液形成中.
- 在血液癌症中EMT-TFs的新功能提供了新的治疗途径.
- 针对EMT-TF或其通路可能为治疗血液性恶性瘤提供创新策略.
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