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通过抑制中性粒细胞会加剧氧化应激和关节炎
Leticija Zlatar1,2, Aparna Mahajan1,2, Marco Muñoz-Becerra1,2
1Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany.
Frontiers in immunology
|August 21, 2023
概括
高盐摄入量会通过损害中性粒细胞功能和增加氧化应激来加剧关节炎. 虽然高盐饮食 (HSD) 恶化了骨质侵蚀,但它
科学领域:
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
- 细胞生物学 细胞生物学
背景情况:
- 西方高盐饮食与自身免疫性疾病有关.
- 盐对关节炎中性粒细胞功能的确切影响尚不清楚.
研究的目的:
- 为了研究化 (NaCl) 对中性粒细胞功能 in vitro 和 in vivo 的影响.
- 在关节炎模型中探索盐和活性氧物种 (ROS) 在骨质细胞活性中的作用.
主要方法:
- 在不同NaCl度下对中性粒细胞活力和功能的体外分析.
- 在体内研究使用K/BxN血清转移性关节炎 (STA) 动物模型.
- 检查骨质细胞分化与NaCl和过氧化 (H2O2) 的暴露.
主要成果:
- 超性NaCl诱导了中性粒细胞亡,抑制了细胞化和NET形成,但增加了ROS和中性粒细胞弹性酶 (NE) 活性.
- 高盐饮食 (HSD) 加剧了关节炎,增加了炎症,骨质侵蚀和骨质细胞分化.
- 在试验室中,NaCl抑制了骨质细胞分化,与H2O2的亲吸收效应形成对比.
结论:
- 高盐饮食引起的关节炎骨质侵蚀可能源于中性粒细胞驱动的氧化应激,而不是直接的NaCl影响.
- 在高盐条件下的中性粒细胞功能障碍有助于关节炎的发病.
- 需要进一步的研究来阐明在自身免疫性疾病中盐,中性粒细胞和骨代谢之间的复杂相互作用.
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