类风湿性关节炎和甲状腺功能低下症:双向的门德尔随机化研究
Lincheng Duan1, Dongqing Chen1, Yue Shi1
1Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Frontiers in immunology
|August 21, 2023
概括
这项研究使用了门德尔的随机化来确认类风湿性关节炎 (RA) 和甲状腺功能低下症之间的双向因果关系. 结果表明RA增加了甲状腺功能低下的风险,甲状腺功能低下增加了RA的风险,突出了双向关系.
科学领域:
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
- 遗传学 遗传学 是一个
背景情况:
- 观察性研究表明,类风湿性关节炎 (RA) 和甲状腺功能低下症之间存在相关性.
- 关节炎和甲状腺功能低下症之间的因果关系尚不清楚.
研究的目的:
- 使用孟德尔随机化 (MR) 调查类风湿性关节炎 (RA) 和甲状腺功能低下症之间的双向因果关系.
主要方法:
- 分析了来自全基因组关联研究 (GWAS) 对欧洲人群的RA和甲状腺功能低下症的总结数据.
- 使用了包括MR-Egger,加权中位数 (WM) 和逆方差加权 (IVW) 在内的孟德尔随机化方法.
- 用MR-Egger拦截,MR-PRESSO,离开一个的分析和Cochran的Q测试来评估性和异质性.
主要成果:
- 建立了双向因果关系:RA增加了甲状腺功能低下的风险 (OR=1.28) 和甲状腺功能低下增加了RA风险 (OR=1.68).
- 二次性甲状腺功能低下症也显示了RA和甲状腺功能低下症的风险增加.
- 在FinnGen财团数据中的复制证实了这些发现,没有证据表明横向类.
结论:
- 这项研究证实了类风湿性关节炎和甲状腺功能低下症之间的双向因果关系.
- 结果表明潜在的共同病因因素或反机制需要进一步调查.
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