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在天生的免疫cGAS-STING信号通路和人类疹病毒感染之间的战斗

Ximing Jin¹, Wenjia Wang¹, Xinwei Zhao¹

¹Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Frontiers in immunology

|August 21, 2023

概括

人类疹病毒 (HHV) 越来越多地威胁着健康. 本综述探讨了cGAS-STING通路的使用情况.

科学领域:

免疫学免疫学免疫学
病毒学病毒学
分子生物学分子生物学

背景情况:

循环GMP-AMP合成酶 (cGAS) 刺激干扰素基因 (STING) 途径是一个重要的先天免疫传感器,用于检测细胞核DNA.
人类疹病毒 (HHV) 很普遍,可以引起严重的疾病,包括瘤和先天性形.
由于它们的发病率不断增加,高高温病毒对全球健康构成了重大挑战.

研究的目的:

阐明cGAS-STING通路在人类疾病,特别是HHV感染中的作用.
突出针对cGAS-STING通路的病毒逃避策略.
为抗病毒药物和疫苗开发提供cGAS-STING通路调节器的概述.

主要方法:

在病毒感染中对cGAS-STING通路的文献综述.
通过cGAS-STING调制来逃避宿主免疫力的病毒机制的分析.
收集针对cGAS-STING通路的小分子化合物的数据.

主要成果:

高血压病毒激活cGAS-STING通路,导致I型干扰素分泌以限制病毒复制.
高血压病毒使用病毒蛋白来抑制cGAS活动并抑制STING-TBK1-IRF3信号,从而逃避免疫监测.
在体外和体内研究表明,在疾病模型中,cGAS-STING通路激活剂和抑制剂具有前途.

结论:

cGAS-STING通路是HHV和宿主免疫之间的关键战场.
准cGAS-STING通路为新型抗病毒疗法和针对HHVs的疫苗提供了潜力.
将cGAS-STING调节器转化为临床应用仍然是一个重大挑战,需要进一步研究.

关键词:

刺痛是一种刺痛.cGAS 是一个气体.人类疹病毒病毒免疫系统逃脱,逃离免疫系统.具有天生的免疫力.

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