移植与宿主疾病:以更低的成本教老药新技巧
Shatha Farhan1, Shernan G Holtan2
1Stem Cell Transplant and Cellular Therapy, Henry Ford Health, Detroit, MI, United States.
Frontiers in immunology
|August 21, 2023
概括
重新利用已知药物可以改善移植对宿主疾病 (GVHD) 的预防和治疗,提高干细胞移植 (SCT) 患者的可访问性. 这篇评论探讨了FDA批准的药物,可能有GVHD管理的仿制版本.
科学领域:
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 移植与宿主疾病 (GVHD) 是全原干细胞移植 (SCT) 的一个显著并发症,影响患者的发病率和死亡率.
- 减少强度治疗方案和人类白细胞抗原 (HLA) 不匹配的进展扩大了SCT资格和供体选择.
- 尽管取得了进展,但对一些患者群体的新型GVHD治疗方法的获取仍然有限.
研究的目的:
- 审查目前关于重新使用现有药物用于GVHD预防和治疗的证据.
- 确定FDA批准的药物,具有长期批准 (自2008年以来),可能提供可访问的治疗选择.
主要方法:
- 文献审查侧重于美国食品和药物管理局 (FDA) 至少15年批准的药物.
- 分析这些药物在GVHD预防和治疗方案中重新使用的潜力.
主要成果:
- 越来越多的临床试验和FDA批准正在GVHD预防和治疗中出现.
- 重新利用旧的,FDA批准的药物可以提供具有成本效益和可访问的GVHD管理策略.
- 预计这些重新定位的药物的通用可用性将进一步提高可访问性.
结论:
- 重用已建立的,FDA批准的药物是解决GVHD预防和治疗挑战的可行策略.
- 这种方法可以克服与新型疗法相关的地理和资源限制.
- 专注于长期批准的药物确保了通用药的可用性和更广泛的患者获取的潜力.
关键词:
一个-1-抗素.博尔特佐米布 (Bortezomib) 是一种药物.药物重用是为了改变药物的用途.接种与宿主病的疾病.人类胆管性淋巴激素人类胆管性淋巴激素在移植后的循环胺胺.西塔格利普丁 (Sitagliptin) 是一种更多相关视频
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