虹膜黑色细胞瘤的血管学特征:神经与黑色素瘤对比
Janani Singaravelu1, Alexander Melendez-Moreno1, Jacquelyn Wrenn1
1Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Ocular oncology and pathology
|August 21, 2023
概括
用光素血管学评估虹膜瘤血管结构有助于区分虹膜黑色素瘤和瘤. 养血管和内在血管表明恶性病变,而血管学沉默表明良性虹膜神经.
科学领域:
- 眼科医生 眼科 眼科
- 在瘤学瘤学.
- 医疗成像医学成像
背景情况:
- 从临床上来说,区分虹膜黑色素瘤和虹膜神经是具有挑战性的.
- 虹膜病变中的瘤血管结构可能有助于诊断.
研究的目的:
- 根据瘤相关血管结构评估前段光素血管学在区分虹膜黑色素瘤和虹膜神经中的实用性.
主要方法:
- 60名患者的回顾性观察研究 (45名虹膜黑色素瘤,15名虹膜神经).
- 评估了临床和灯摄影特征.
- 评估的光素血管学参数:输送血管,内在血管,泄漏,掩盖和血管学沉默.
主要成果:
- 在43%的黑色素瘤中存在输送血管,而在瘤中则为0% (p=0.002).
- 在83%的黑色素瘤和33%的瘤中观察到内在血管 (p=0.001).
- 光素泄漏在黑色素瘤 (98%) 中显著高于瘤 (60%) (p=0.001).
- 血管静止发生在20%的瘤中,但0%的黑色素瘤中 (p=0.017).
- 内在血管 +/- 料血管对黑色素瘤显示了85%的灵敏度和87%的积极预测值.
结论:
- 前段光血管学对于区分虹膜瘤和黑色素瘤是有用的.
- 料血管的存在是虹膜黑色素瘤的特征.
- 内在血管和光素泄漏与虹膜黑色素瘤有关.
- 血管造影静止是虹膜瘤的迹象.
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