在TIPS后预测明显的肝脑病变:三个最小肝脑病变测试的值
Alena F Ehrenbauer1,2, Hannah Schneider1, Lena Stockhoff1
1Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany.
JHEP reports : innovation in hepatology
|August 21, 2023
概括
像PSE,ANT和CFF这样的最小肝脑病变 (mHE) 测试在插入横性肝脏内移植系统分流 (TIPS) 后预测明显肝脑病变 (HE) 的价值有限. 认知功能在TIPS后保持稳定.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 神经学 神经学
- 临床诊断 临床诊断 临床诊断
背景情况:
- 肝脏脑病变 (HE) 是一个严重的并发症后的transjugular 肝脏内移植系统 (TIPS) 插入.
- 对于TIPS后的HE的风险因素还没有得到很好的定义.
- 最小的HE (mHE) 是在没有TIPS的肝硬化患者中明显的HE的已知预测因子.
研究的目的:
- 评估三种mHE诊断工具的动态变化和预测价值,用于TIPS之后的开放式HE.
- 评估PSE综合征测试,动物命名测试 (ANT) 和临界闪频率 (CFF) 在预测TIPS后HE的有用性.
主要方法:
- 84名接受TIPS治疗的患者的前性观察性研究.
- 患者在TIPS插入前后使用PSE,ANT和CFF对mHE进行了测试.
- 在TIPS HE后进行180天的监测.
主要成果:
- 25名患者 (29.8%) 在180天内发展出明显的HE.
- 在基线时,mHE的患病率为66.3% (PSE),64.6% (ANT) 和28.4% (CFF).
- 这三种测试都没有显著预测TIPS后的HE;性能在TIPS后保持稳定.
结论:
- 在接受TIPS的患者中,PSE,ANT和CFF对公开的HE的预测价值有限.
- 提示插入似乎不会导致长期的心理测量下降.
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