静脉血栓塞栓症中的手握强度:复发风险和死亡率
Oda G R Leknessund1, Vania M Morelli1,2, John-Bjarne Hansen1,2
1Thrombosis Research Group, Department of Clinical Medicine, UiT - The Arctic University of Norway, Tromsø, Norway.
Research and practice in thrombosis and haemostasis
|August 21, 2023
概括
软弱的手握力 (HGS) 与静脉血栓栓塞 (VTE) 复发和死亡率的风险更高有关. 这项研究强调了HGS作为VTE患者潜在的预后因素.
科学领域:
- 心血管医学 心血管医学
- 临床流行病学临床流行病学
- 老年学是一门学科.
背景情况:
- 关于肌肉强度和静脉血栓塞栓症 (VTE) 后的结果之间的关联存在有限的数据.
- 手握强度 (HGS) 是总体肌肉强度的一个易于测量的指标.
- 调查VTE患者的HGS可能会揭示预后见解.
研究的目的:
- 确定手握强度 (HGS) 的降低是否预测了首次静脉血栓塞栓症 (VTE) 患者的复发和死亡率.
- 在一般人口队列中评估弱HGS和VTE复发风险之间的关联.
主要方法:
- 分析了来自特罗姆索研究 (1994-2020年) 的545名首次出现静脉瘤患者的队列.
- 弱HGS被定义为一般人口HGS最低的第25百分位.
- 对于VTE复发和死亡率的发病率和危险比率 (HR) 计算了弱和正常的HGS组.
主要成果:
- 较弱的HGS与整体VTE复发风险增加2.02倍相关 (HR:2.02;95% CI,1.23-3.30).
- 与肺栓塞 (HR: 1.60) 相比,深静脉血栓 (HR: 2.22) 的复发风险更高.
- 在HGS较弱的患者中,总死亡风险增加了1.34倍 (HR: 1.34; 95% CI, 1.04-1.72).
结论:
- 减少手握强度是增加静脉瘤复发风险的重要预测因素,特别是在深静脉血栓形成后.
- 与正常HGS患者相比,弱HGS患者的1年生存概率略低.
- 在VTE的管理中,HGS可以作为一个有价值的预后标记.
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