血清微量元素与不补偿性肝硬化患者睡眠障碍之间的关联
Ziyue Zhang1,2, Yangyang Hui3, Wanting Yang3
1Department of Otorhinolaryngology Head and Neck Surgery, Tianjin First Central Hospital, Nankai District, Tianjin, China.
Therapeutic advances in chronic disease
|August 21, 2023
概括
患有不补偿性肝硬化症的患者通常会经历与微量元素不平衡相关的睡眠障碍. 较高的铜/比 (CZr) 被确定为这些患者睡眠质量差的一个独立风险因素.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 营养科学 营养科学
- 睡眠医学 睡眠医学
背景情况:
- 睡眠障碍和微量元素不平衡在不补偿性肝硬化中很普遍.
- 这些条件都有潜在的机械联系,但它们之间的关系仍未得到充分研究.
研究的目的:
- 为了研究血清微量元素水平和不补偿性肝硬化患者的睡眠质量之间的关联.
主要方法:
- 一项横截面研究招募了160名缺乏补偿的肝硬化患者.
- 使用匹兹堡睡眠质量指数 (PSQI) 评估睡眠质量.
- 测量了血清中,,铁,铜 (Cu), (Zn),和的含量;计算了Cu/Zn比率 (CZr).
主要成果:
- 睡眠障碍 (PSQI>5) 在56.88%的患者中存在.
- 睡眠质量不佳的患者血清Cu水平显著提高,CZr也更高.
- 较高的CZr被确定为睡眠障碍的独立风险因素 (OR=2.364,p=0.019).
结论:
- 较高的铜/比 (CZr) 与不补偿性肝硬化症的睡眠障碍有关.
- 在这种患者群体中,CZr可以作为睡眠障碍的潜在生物标志物.
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