树根瘤 Atractylodis Macrocephalae-评估草药加工方法的影响和改善对功能性消化不良的影响
Song-Hong Yang1, Jing Zhu1, Wen-Ting Wu1
1School of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang, China.
Frontiers in pharmacology
|August 21, 2023
概括
用Aurantii Fructus Immaturus (AFI) 处理Rhizoma Atractylodis Macrocephalae (AMR) 通过改变代谢物和调节关键路径,提高其对功能性消化不良 (FD) 的疗效,为TCM草药制备提供了一种新的方法.
科学领域:
- 药理学 药理学是指药理学的学科.
- 代谢学 代谢学 代谢学
- 传统中国医学 (TCM) 是一种
背景情况:
- TCM加工方法对植物药物的疗效和临床应用有重大影响.
- 了解加工草药中的代谢物变化对于阐明作用机制至关重要.
研究的目的:
- 为了研究由Aurantii Fructus Immaturus (AFI) 蒸加工的Rhizoma Atractylodis Macrocephalae (AMR) 中的代谢物变化.
- 阐明这些变化如何提高功能性消化不良 (FD) 的治疗疗效.
主要方法:
- 使用UPLC-Q-TOF-MS/MS和HPLC进行定性和定量代谢物分析.
- 网络分析 (BMTD和PPI) 用于预测洞察力.
- 在功能性消化不良的老鼠模型中进行验证.
主要成果:
- 在加工AMR (PAMR) 中发现了127种代谢物;8种关键代谢物显示出显著的变化.
- PAMR水性提取物证明了FD治疗效率的提高.
- 通过DRD2,SCF,c-kit调制增强抗炎和胃运动效应,并减弱了MTL,GAS,Ach,AchE调节.
结论:
- 在AFI蒸加工方法显著改变AMR代谢物.
- 这种处理通过调节特定的分子点来增强FD的治疗效果.
- 结果提供了对优化TCM草药配方临床疗效的见解.
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