与COVID-19疫苗接种相关的自身免疫性肝炎 - 一个视角
1AP Division, Pathology Laboratories, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON, Canada.
Frontiers in pharmacology
|August 21, 2023
概括
使者RNA (mRNA) 疫苗可能引发自身免疫性肝炎 (AIH) 和其他自身免疫性疾病. 研究表明,在某些肌痛性骨髓灰质炎患者中发现的抗滴抗体与潜在的疫苗相关的自身免疫现象之间存在联系.
科学领域:
- 免疫学 免疫学 免疫学
- 肝病学 肝病学是一种肝病学.
- 疫苗学 疫苗学 疫苗学
背景情况:
- 自身免疫性肝炎 (AIH) 是一种肝炎,其特征是特定的组织学发现和自身抗体.
- 随着COVID-19大流行,mRNA疫苗 (Pfizer-BioNTech,Moderna) 的快速开发和部署成为可能.
- 在mRNA疫苗接种后报告了包括心肌炎和AIH在内的不良事件.
研究的目的:
- 探索mRNA疫苗与自身免疫现象,特别是AIH之间的潜在联系.
- 调查滴蛋白和抗滴抗体在与疫苗相关的自身免疫疾病中的作用.
- 在接种疫苗的背景下,评估共存的骨髓灰质炎和AIH的相关性.
主要方法:
- 对AIH,mRNA疫苗和自身免疫性疾病的现有数据和文献的审查.
- 与心肌炎相关的蒂蛋白结构的比较.
- 对患有肌痛性骨髓灰质炎和潜在的疫苗相关自身免疫的患者的抗滴素抗体的发现进行分析.
主要成果:
- 抗滴素抗体在患有肌痛性骨髓灰质炎的患者的一个子组中被发现.
- 骨髓灰质炎和AIH的共存并不常见,但显著.
- 假定mRNA疫苗接种与自身免疫现象 (包括AIH) 之间存在潜在的关联.
结论:
- 在mRNA疫苗接种后,自身免疫现象,可能包括AIH,可能并不罕见.
- 抗滴素抗体的存在可能是疫苗相关自身免疫的相关标志物.
- 在考虑mRNA疫苗增剂时,谨慎平衡好处和风险至关重要.
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