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案例报告:Hb E异性对Tosoh HLC-723G11的HbA1c值的影响

Wei Gao¹, Wenyu Li¹, Qian Zheng²

¹Health Management Center, General Practice Center, West China Hospital, Sichuan University, Chengdu, China.

Frontiers in public health

|August 21, 2023

概括

血红蛋白E (Hb E) 异性可能导致HbA1c读数降低,可能掩盖糖尿病前期. 托索HLC-723G11分析仪可以检测出这种变异,但需要进一步测试才能确诊.

科学领域:

临床化学临床化学
血液学血液学血液学
遗传学是一个遗传学.

背景情况:

糖化血红蛋白 (HbA1c) 是糖尿病监测的关键标志物.
血红蛋白变体,如Hb E,可以干扰HbA1c测量.
准确的HbA1c测定对于糖尿病诊断和管理至关重要.

研究的目的:

为了研究Hb E异性对HbA1c值的影响.
评估Tosoh HLC-723G11分析仪在检测Hb E.中的性能.
突出Hb E和低HbA1c患者的潜在诊断挑战.

主要方法:

一个病人的病例报告异常低HbA1c.
使用Tosoh HLC-723G11分析仪对HbA1c的分析.
血红蛋白电泳和对β-thalassemia和HbE的基因检测.

主要成果:

一名45岁的中国妇女的HbA1c为3.7%,低于正常范围.
托索HLC-723G11显示异常峰值,血红蛋白电泳证实了25.1%的HbE.
基因分析显示了βE M/N和CD26 (A>G) 突变;口服耐葡萄糖测试表明糖尿病前期.

结论:

Hb E 异性可以错误地降低 HbA1c 测量值,正如Tosoh HLC G11所检测的那样.
托索HLC G11分析仪可以有效地识别HbE变异.
建议进行进一步的血糖监测测试,以避免在怀疑Hb E和低HbA1c的个体中误诊,等待更大的研究.

关键词:

Hb E 这是一个很好的例子.这就是HbA1c.在Tosoh HLC-723G1111中使用.异构性异构性是指异构性.高压液体色谱学高压液体色谱学

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