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对2'-脱氧-ATP对心肌处理的影响的多尺度计算建模

Marcus T Hock1, Abigail E Teitgen1, Kimberly J McCabe2

  • 1Department of Bioengineering, University of California San Diego, La Jolla, California 92093, USA.

Journal of applied physics
|August 21, 2023
PubMed
概括

2'-脱氧-ATP (dATP) 通过加速的再吸收来增强心脏功能. 这项研究揭示了dATP改善了SERCA的活动,导致心肌细胞中的衰变更快.

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Cardiac Output I:Effect of Heart Rate on Cardiac Output01:19

Cardiac Output I:Effect of Heart Rate on Cardiac Output

Cardiac Output
Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
Effect of Heart Rate on Cardiac Output
Cardiac output adapts to metabolic demands during stress, physical activity, or illness. The autonomic nervous system regulates heart rate via the sinoatrial node. The parasympathetic nervous system decreases heart rate...