巴西的肉携带的Campylobacter jejuni的多种病毒性
Phelipe Augusto Borba Martins Peres1, Roberta Torres de Melo1, Paulo Marcel Armendaris2
1Laboratório de Epidemiologia Molecular - LEPIMOL/UFU, Uberlândia, Minas Gerais, Brazil.
Frontiers in microbiology
|August 21, 2023
概括
巴西的肉含有众多毒性Campylobacter jejuni菌株,构成公共卫生风险. 需要采取紧急的监测和控制措施,特别是在巴拉纳州,以减轻胃肠炎和吉-巴雷综合征的风险.
科学领域:
- 食品安全 食品安全
- 微生物学 微生物学
- 公共卫生 公共卫生
背景情况:
- 全球范围内,Campylobacter jejuni是导致细菌性胃肠炎的主要原因.
- 调查C. jejuni流行病学对公共卫生至关重要,特别是在巴西等主要食品出口国.
- 了解肉尸中C. jejuni菌株的毒性因素对于风险评估至关重要.
研究的目的:
- 为了评估来自巴西肉尸体的C. jejuni菌株中14个毒性基因的流行率.
- 确定与这些菌株相关的潜在公共卫生风险,包括感染和吉兰-巴雷综合征.
- 在巴西绘制病毒性C. jejuni菌株的地理分布和季节变化图.
主要方法:
- 在巴西从冷的肉尸中分离出来的359种C. jejuni菌株的分析.
- 将14个毒性基因分为五类:生物膜/运动性,分泌/细胞毒性,入侵/殖民性,吉兰-巴雷和适应压力.
- 地理引用和分析菌株的变异性,按尸体,屠宰场和市镇进行分析.
主要成果:
- 压力适应基因 (86.07%) 和hcp基因 (97.77%) 的高流行率,表明生存和人类感染潜力.
- 发现了与吉-巴雷综合征相关基因的显著存在 (77.44%).
- 在不同地理位置观察到病毒性基因配置的高变异性,帕拉纳州被确定为热点. 夏季观察到更高的隔离和多病毒性.
结论:
- 来自巴西肉尸体的C. jejuni菌株对公众健康构成重大危险.
- 迫切需要加强监测和控制战略,特别是在帕拉纳地区.
- 这些发现强调了监测毒性因素和地理分布的重要性,以减轻与C. jejuni.相关的风险.
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