含硫元素的人类健康中的代谢途径和与微生物群的交叉交叉
Austin W Hansen1, Kallidaikurichi V Venkatachalam1
1College of Allopathic Medicine, Nova Southeastern University, Fort Lauderdale, FL, 33328, USA.
Biochemistry and biophysics reports
|August 21, 2023
概括
饮食中的甲因对人类健康至关重要,它支持硫代谢并产生无机硫物种 (ISS). 肠道微生物群也影响这些硫路径,影响整体健康.
科学领域:
- 生物化学 生物化学
- 微生物学 微生物学
- 人体生理学 人体生理学
背景情况:
- 来自饮食中的甲氨酸对于细胞过程和硫化合物合成至关重要.
- 无机硫种 (ISS) 越来越多地被认为对人类健康和肠道微生物群相互作用的作用.
- 内源性ISS包括硫化,硫酸盐,硫酸盐和硫酸盐,通过特定的代谢途径产生.
研究的目的:
- 审查硫在生物通路中的系统性影响.
- 阐明蛋白质翻译后修改中的硫化和化对比机制.
- 检查肠道微生物在人类硫代谢中的作用.
主要方法:
- 文献综述侧重于硫代谢,翻译后修改和肠道微生物组.
- 对参与硫化合物生产的酶途径的分析.
- 调查微生物对宿主硫池的贡献.
主要成果:
- 含硫的通路对于细胞平衡和再生至关重要.
- 肠道细菌,特别是硫酸盐降解细菌 (SRB),对主机无机硫物种池有着显著的贡献.
- 硫化和化代表着不同的翻译后修饰策略.
结论:
- 硫代谢受饮食和肠道微生物群的影响,在人类健康中起着至关重要的作用.
- 了解硫化与化对比,为蛋白质调节提供了洞察力.
- 肠道微生物组是宿主硫平衡的关键调节器.
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