口服胃镜疗法的有效性 对于完整的远端肠道阻塞综合征
Hugh L Giddings1,2, Jared McNeill1, Bayzidur Rahman3,4
1From the Department of General Surgery, St Vincent's Hospital, Sydney, Australia.
概括
口服Gastrografin有效地治疗囊性纤维化患者的完全远端肠道阻塞综合征 (cDIOS). 这种安全的第一线治疗显示出较低的失败率,减少了对手术的需要.
科学领域:
- 胃肠病学 胃肠病学
- 肺部病理学 肺部病理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 远端肠道阻塞综合征 (DIOS) 是囊性纤维化 (CF) 患者的一个显著并发症.
- 目前对cDIOS的保守治疗方法是经验性的,最佳管理策略仍在研究中.
- 外科手术通常只适用于那些难以接受非手术治疗的病例或有立即手术指示的病例.
研究的目的:
- 评估口服Gastrografin治疗成年囊性纤维化 (CF) 患者完全偏远肠道阻塞综合征 (cDIOS) 的疗效和结果.
- 评估与口服胃素治疗相关的安全性和治疗失败率.
- 为了确定口服Gastrografin是否可以被视为CF中cDIOS的主要治疗方法.
主要方法:
- 在一个单一的机构进行了一项回顾性队列研究.
- 包括接受肺移植和在2004年至2020年间经历cDIOS的成年CF患者.
- 分析了接受常规口服Gastrografin治疗的患者的治疗结果.
主要成果:
- 在124名肺移植CF患者中,29名患者发生了47次cDIOS发作;平均年龄为30.3岁.
- 口服胃素在95.7%的发作中被使用,只有7.0%的患者因治疗耐药性而需要腹腔切除术.
- 腹部手术史与cDIOS发展有显著的关联 (P < 0.001);没有死亡归因于DIOS.
结论:
- 口服胃素证明了在成人CF患者中管理cDIOS的有效性和安全性.
- 较低的治疗失败率支持其作为cDIOS的第一线选择.
- 这种方法可以减少对完全偏远肠道阻塞的CF患者进行手术的需要.
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