布鲁加达综合征患者的麻醉学管理:系统性审查
Giuseppe Cuttone1, Gennaro Martucci2, Ruggero Napoli1
1Department of Anesthesia and Intensive Care, ASP Trapani, S.A. Abate Hospital, Erice, Italy.
Saudi journal of anaesthesia
|August 21, 2023
概括
布鲁加达综合征 (BrS) 患者的麻醉药物安全性研究较少. 普罗波似乎安全用于全身麻醉,而利多卡因可能适用于BrS患者的局部麻醉.
科学领域:
- 心脏病学 心脏病学
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
背景情况:
- 布鲁加达综合征 (BrS) 是心脏突然死亡和心室动脉节律失常的重要危险因素.
- 某些麻醉药物在BrS患者中是禁忌的,但对其安全性的证据有限.
- 关于在BrS患者中安全使用常见麻醉药物的数据有限.
研究的目的:
- 系统地审查关于在麻醉和重症监护期间对BrS患者的药理管理的文献.
- 为了确定BrS中的麻醉剂的前节律效应和潜在的药物相互作用.
- 评估现有证据的质量,关于麻醉药物的安全性在布鲁塞尔.
主要方法:
- 在PubMed的系统文献搜索到2022年10月10日.
- 包括关于在麻醉或重症监护期间对BrS患者的药理管理的研究.
- 专注于BrS背景下的前节律失常效应和药物相互作用.
主要成果:
- 搜索结果显示了44个相关项目,但只有三个原始研究 (两个RCT,一个前性研究).
- 分析了199名接受全身或局部麻醉的患者的数据,主要来自病例系列和报告.
- 普罗波在全身麻醉中似乎是安全的;与长效药物相比,可能更喜欢用利多卡因进行区域麻醉.
结论:
- 现有的关于brs患者麻醉管理的研究质量通常很差.
- 进一步的高质量,大规模的多中心研究或国际注册表对于建立BrS的安全麻醉方案至关重要.
- 目前的证据表明,普罗波福在全身麻醉中安全,而利多卡因在BrS患者的局部麻醉中安全.
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