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中枢神经系统中的细胞和血管光滑肌细胞 动脉静脉形形
Sera Nakisli1,2, Alfonso Lagares3,4,5, Corinne M Nielsen1,2,6
1Department of Biological Sciences, Ohio University, Athens, OH, United States.
Frontiers in physiology
|August 21, 2023
概括
墙体细胞,包括皮质细胞和血管光滑肌细胞,越来越多地被认为是它们在中枢神经系统 (CNS) 动脉静脉形 (AVM) 中的作用. 研究强调了它们的异质性和参与AVM的发展和病理.
科学领域:
- 神经科学是一个神经科学.
- 血管生物学 血管生物学
- 细胞生物学 细胞生物学
背景情况:
- 壁细胞 (pericytes和血管光滑肌细胞) 曾经被视为被动支持细胞.
- 最近的发现揭示了各种各样的壁画细胞亚型,具有不同的形态,基因表达和功能.
- 中枢神经系统 (CNS) 动脉静脉形 (AVMs) 是神经血管疾病,其中壁细胞的参与越来越明显.
研究的目的:
- 审查人类中枢神经系统AVM样本中已知对壁画细胞的影响.
- 总结关于壁画细胞的中枢神经系统AVM动物模型的发现.
- 探索将壁细胞功能障碍与AVM联系起来的潜在机制.
主要方法:
- 对人类中枢神经系统AVM样本的现有文献的审查.
- 从中枢神经系统AVM的各种动物模型中分析数据.
- 在AVM中合成壁画细胞的分子,细胞和功能特征.
主要成果:
- 在AVM中,壁细胞在分子,细胞和功能方面表现出显著的异质性.
- 在人类中枢神经系统AVM和相关动物模型中都观察到壁画细胞的乱.
- 有证据表明,壁细胞病理与AVM发展密切相关.
结论:
- 壁细胞在中枢神经系统AVMs的发病过程中发挥着关键的,非被动的作用.
- 壁画细胞和AVM的异质性是理解这种神经血管疾病的关键因素.
- 对壁细胞机制的进一步研究对于AVM治疗策略至关重要.
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