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胸腔腹腔大动脉动脉瘤修复前后使用G分支内移植进行大动脉血液动力学和形态学分析
Jiabin Wang1,2, Tingting Fan3, Hongpeng Zhang1
1The First Medical Centre, Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, Beijing, China.
Frontiers in physiology
|August 21, 2023
概括
G分支内移植有效地修复了胸腔腹腔大动脉动脉瘤 (TAAA),改善了血液流动和血管形态. 血液动力学分析显示,植入后血液流动更顺,更快,再循环区域减少.
科学领域:
- 血管外科 血管外科
- 医疗设备工程 医疗设备工程
- 生物医学流体动力学
背景情况:
- 胸腔腹腔大动脉瘤 (TAAA) 带来了重大的修复挑战.
- G-Branch内移植是一种创新的"现成"设备,用于TAAA治疗.
- 评估新型内移植的血液动力学和形态学性能至关重要.
研究的目的:
- 评估人类TAAA患者G分支内移植的血液动力学和形态学性能.
- 在G分支内移植植入后分析血液流动模式和血管几何的变化.
主要方法:
- 计算机断层扫描扫描和临床数据的回顾性审查.
- 创建患者特定的3D模型进行分析.
- 计算流体动力学 (CFD) 对植入前和后的形态和血液动力学指标的分析.
主要成果:
- 随着时间的推移,内移植和桥梁支架移植的横截面积增加.
- 血液流向再生动脉的重新分配,在特定的血管中改变了流量.
- 植入后更平滑,更快的层状血流;在桥梁和密封区域确定了流量循环回流区;改善了血液动力学指标 (墙壁剪切应力,振荡指数,相对居住时间).
结论:
- G-Branch内移植植入促进了分支血管的再血管化.
- 在TAAA修复的改善归因于形态和血液动力学变化.
- 需要对G分支内移植进行进一步的临床验证和长期性能研究.
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